Can you get buspirone

HT type 1A receptors

Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate: Theoretically, concurrent use of methylene blue and buspirone may increase the risk of serotonin syndrome. Methylene blue is a thiazine dye that is also a potent, reversible inhibitor of the enzyme responsible for the catabolism of serotonin in the brain MAO-A and buspirone increases central serotonin effects. Talk to your doctor or about lifestyle changes that might benefit you. Amphetamines may delay intestinal absorption of ethosuximide. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. can you get indinavir

National Institute Of Health

Doxylamine: The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Carbetapentane; Guaifenesin: Drowsiness has been reported during administration of carbetapentane. An enhanced CNS depressant effect may occur when carbetapentane is combined with other CNS depressants including buspirone.

Rossi, S, ed 2013

Hydrocodone; Pseudoephedrine: Concomitant use of hydrocodone with other central nervous system depressants, such as buspirone, can potentiate the effects of hydrocodone and may lead to additive CNS or respiratory depression. If hydrocodone is used with buspirone, the dose of one or both drugs should be reduced. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Clozapine: The combination of buspirone and CNS depressants like the antipsychotics can increase the risk for drowsiness, sedation, and dizziness.

Buspirone uses

Metoclopramide: Combined use of metoclopramide and other CNS depressants, such as anxiolytics, sedatives, and hypnotics, can increase possible sedation. Chlophedianol; Dexchlorpheniramine; Pseudoephedrine: The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation. Efavirenz: Substances that are inducers of hepatic cytochrome P450 isoenzyme CYP3A4, such as efavirenz, may increase the rate of buspirone metabolism. In a study of healthy volunteers, co-administration of buspirone with rifampin decreased the plasma concentrations 83. AUC and pharmacodynamic effects of buspirone. If a patient has been titrated to a stable dosage on buspirone, a dose adjustment of buspirone may be necessary to maintain anxiolytic effect.



What other drugs will affect buspirone

Ask your pharmacist about using these products safely. Milnacipran: Because of the potential risk and severity of serotonin syndrome or neuroleptic malignant syndrome-like reactions, caution should be observed when administering serotonin norepinephrine reuptake inhibitors SNRIs with other drugs that have serotonergic properties such as buspirone. Atazanavir: When buspirone is administered with an inhibitor of CYP3A4 like atazanavir, a lower dose of buspirone is recommended. Dose adjustment of either drug should be based on clinical assessment. The information on this page is not a substitute for the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that a drug or drug combination is safe, effective or appropriate for any given patient. Drugs. Take buspirone exactly as directed by your doctor. Impotence, changes in libido, frequent or prolonged erections. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Telaprevir: Close clinical monitoring is advised when administering buspirone with telaprevir due to an increased potential for buspirone-related adverse events. If buspirone dose adjustments are made, re-adjust the dose upon completion of telaprevir treatment. Although this interaction has not been studied, predictions about the interaction can be made based on the metabolic pathway of buspirone. Buspirone is metabolized by the hepatic isoenzyme CYP3A4; telaprevir inhibits this isoenzyme. Coadministration may result in elevated buspirone plasma concentrations. Compare prices and print coupons for Buspirone Buspar and other Anxiety drugs at CVS, Walgreens, and other pharmacies. Your doctor may increase your daily dose by 5 mg every few days if needed. Buspar usual adult starting dose is 10-30mg daily in 2-3 divided doses up to a maximum of 60mg a day.



What is the dosage for buspirone?

In 2001, the FDA approved a generic version of buspirone for several drug manufacturers, and Bristol-Myers Squibb discontinued the brand name BuSpar. Elks 14 November 2014. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Skin: Infrequent were edema, pruritus, flushing, easy bruising, hair loss, dry skin, facial edema, and blisters; rare were acne and thinning of nails. To reduce your risk of side effects, your doctor may start you at a low dose and then gradually increase your dose. Once your condition improves and you are better for a while, your doctor may work with you to reduce your regular dose. Follow your doctor's instructions carefully. not take more or less medication or take it more frequently than prescribed. Your condition will not improve any faster and your risk of side effects will increase. The Journal of Family Practice. 50 3: 203. Ziprasidone: The combination of buspirone and CNS depressants like the antipsychotics can increase the risk for drowsiness, sedation, and dizziness. Pentobarbital: Substances that are potent inducers of hepatic cytochrome P450 isoenzyme CYP3A4, such as barbiturates, may increase the rate of buspirone metabolism. If a patient has been titrated to a stable dosage on buspirone, a dose adjustment of buspirone may be necessary to maintain anxiolytic effect. There is also a risk of additive CNS depression when buspirone is given concomitantly with barbiturates. This should not be used if you have certain medical conditions. Masdrakis VG, Turic D, Baldwin DS 2013. "Pharmacological treatment of social anxiety disorder". Mod Trends Pharmacopsychiatri. If you get any side effects, talk to your doctor or pharmacist. Atropine; Hyoscyamine; Phenobarbital; Scopolamine: Substances that are potent inducers of hepatic cytochrome P450 isoenzyme CYP3A4, such as barbiturates, may increase the rate of buspirone metabolism. If a patient has been titrated to a stable dosage on buspirone, a dose adjustment of buspirone may be necessary to maintain anxiolytic effect. There is also a risk of additive CNS depression when buspirone is given concomitantly with barbiturates. Aprepitant, Fosaprepitant: Use caution if buspirone and aprepitant, fosaprepitant are used concurrently and monitor for an increase in buspirone-related adverse effects for several days after administration of a multi-day aprepitant regimen. In vitro, buspirone is a CYP3A4 substrate. Clarithromycin: Concomitant administration of clarithromycin with buspirone may result in increases in buspirone AUC; the mechanism is probably reduced buspirone metabolism via CYP3A4. A low dose of buspirone is recommended if administered with significant CYP3A4 inhibitors. Subsequent dose adjustments should be based on clinical assessment. serophene



What happens if I overdose Buspar?

This medicine contains lactose. Levorphanol: Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of levorphanol, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use of codeine and buspirone is imperative, reduce the dose of one or both drugs. Squibb Company September, 2007. Buspirone isn't for treating occasional stress associated with everyday life. Rather, doctors prescribe buspirone for anxiety disorder and short-term relief of anxiety symptoms. Tell your doctor if your condition does not improve or if it worsens. Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine: Concomitant use of hydrocodone with other central nervous system depressants, such as buspirone, can potentiate the effects of hydrocodone and may lead to additive CNS or respiratory depression. If hydrocodone is used with buspirone, the dose of one or both drugs should be reduced. Each tablet contains 10 mg buspirone hydrochloride. ases.info casodex



Buspirone dosage

While using buspirone, you may need frequent blood tests at your doctor's office. Aspirin, ASA; Pravastatin: In vitro studies showed that therapeutic levels of aspirin, ASA increased the plasma concentrations of free buspirone by 23% through plasma protein binding displacement. In vivo interaction studies with these drugs have not been performed. Also, the drug may pass through breast milk, but it's not known whether it's safe to take buspirone while breastfeeding. Brompheniramine; Pseudoephedrine: The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation. Amphetamines enhance the adrenergic effect of norepinephrine. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. An in vitro protein binding study indicated that approximately 86% of buspirone is bound to plasma proteins. It was also observed that aspirin increased the plasma levels of free buspirone by 23%, while flurazepam decreased the plasma levels of free buspirone by 20%. However, it is not known whether these drugs cause similar effects on plasma levels of free buspirone in vivo, or whether such changes, if they do occur, cause clinically significant differences in treatment outcome. An in vitro study indicated that buspirone did not displace highly protein bound drugs such as phenytoin, warfarin, and propranolol from plasma protein, and that buspirone may displace digoxin. Sudden death has been reported in association with CNS stimulant treatment at usual doses in children and adolescents with structural cardiac abnormalities or other serious heart problems. Ask your pharmacist about the safe use of those products. Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine: Theoretically, concurrent use of methylene blue and buspirone may increase the risk of serotonin syndrome. Methylene blue is a thiazine dye that is also a potent, reversible inhibitor of the enzyme responsible for the catabolism of serotonin in the brain MAO-A and buspirone increases central serotonin effects. Tell your doctor about any mental problems you or your child have, or about a family history of suicide, bipolar illness, or depression. Mifepristone, RU-486: Strong CYP3A4 inhibitors, such as mifepristone, may decrease systemic clearance of buspirone leading to increased concentrations or prolonged effects. Guaifenesin; Hydrocodone: Concomitant use of hydrocodone with other central nervous system depressants, such as buspirone, can potentiate the effects of hydrocodone and may lead to additive CNS or respiratory depression. If hydrocodone is used with buspirone, the dose of one or both drugs should be reduced. Aspirin, ASA; Dipyridamole: In vitro studies showed that therapeutic levels of aspirin, ASA increased the plasma concentrations of free buspirone by 23% through plasma protein binding displacement. In vivo interaction studies with these drugs have not been performed. The anorectic and stimulatory effects of amphetamines may be inhibited by lithium carbonate. buy nortriptyline zamiennik



How to take buspirone

Protriptyline: Because of the potential risk and severity of serotonin syndrome, caution should be observed when administering tricyclic antidepressants TCAs with other drugs that have serotonergic properties such as buspirone. Buspirone increases the sensitivity of postsynaptic serotonin receptors and TCAs inhibit the reuptake of serotonin. This includes any possible side effects not listed in this leaflet. Propoxyphene: Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of propoxyphene, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use of codeine and buspirone is imperative, reduce the dose of one or both drugs. Nalbuphine: Concomitant use of nalbuphine with other CNS depressants, such as buspirone, can potentiate the effects of nalbuphine on respiratory depression, CNS depression, and sedation. Levomethadyl: Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of levomethadyl, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use of codeine and buspirone is imperative, reduce the dose of one or both drugs. Take this by with or without food, usually once daily or as directed by your doctor. Swallow the capsules whole. not crush or chew the capsules. Doing so can release all of the drug at once and may increase your risk of side effects. Prochlorperazine: Phenothiazines can potentiate the CNS-depressant action of other drugs such as buspirone. Caution should be exercised during simultaneous use of these agents due to potential excessive CNS effects or additive hypotension. Pregabalin: Concomitant administration of pregabalin with CNS depressant drugs, including buspirone, can potentiate the CNS effects of either agent. order cheap rifampicin store otc



There may be new information

Compare Buspirone Prices - GoodRx", "side_effects_page": "Buspirone Side Effects, Information and Pricing - GoodRx", "medicare_seo_page": "Buspirone Medicare Coverage and Co-Pay Details - GoodRx", "price_page": "Buspirone Prices and Buspirone Coupons - GoodRx", "info_page": "What is Buspirone? Dalfopristin; Quinupristin: CYP3A4 inhibitors, such as dalfopristin; quinapristin, may decrease systemic clearance of buspirone leading to increased or prolonged effects. Because of that, you shouldn't drive, operate dangerous machinery, or participate in any risky activities until you know how buspirone affects you. The tablets are scored and can be divided into equal doses. Medicines Compendium. Actavis UK Ltd. Fluoxetine; Olanzapine: The combination of buspirone and CNS depressants like the antipsychotics can increase the risk for drowsiness, sedation, and dizziness. Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine: The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation. You may take buspirone with or without food but take it the same way each time. Aspirin, ASA; Oxycodone: Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of oxycodone, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use of codeine and buspirone is imperative, reduce the dose of one or both drugs. In vitro studies showed that therapeutic levels of aspirin, ASA increased the plasma concentrations of free buspirone by 23% through plasma protein binding displacement. In vivo interaction studies with these drugs have not been performed. Increased blood concentrations may increase side effects while decreased blood concentrations may reduce efficacy. If you have been switched to buspirone from another anxiety medication, you may need to slowly decrease your dose of the other medication rather than stopping suddenly. Some anxiety medications can cause withdrawal symptoms when you stop taking them suddenly after long-term use. Other medications can affect the removal of from your body, which may affect how this works. Switching from one of these drugs to buspirone will not prevent a withdrawal reaction because buspirone does not act like these other medications. Instead, you have to taper down the dose of the drugs gradually. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Always consult your doctor or healthcare specialist for medical advice.



Buspirone drug interactions

Metaxalone: Concomitant use of skeletal muscle relaxants with buspirone can result in additive CNS depression. Dosage adjustments of either or both medications may be necessary. It may harm them and it is against the law. National Institute Of Health. FDA pregnancy category B. Buspirone is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Acetaminophen; Diphenhydramine: The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation. Lopinavir; Ritonavir: When buspirone is administered with a potent inhibitor of CYP3A4 like ritonavir, a low dose of buspirone used cautiously is recommended. Some patients receiving drugs that are potent inhibitors of CYP3A4 with buspirone have reported lightheadedness, asthenia, dizziness, and drowsiness. It is against the law. The above symptoms would not be due to another mental disorder, such as a depressive disorder or schizophrenia. However, mild depressive symptoms are common in GAD. Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets Mixed Salts of a Single Entity Amphetamine Product for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient. japanese eskazole



Side effects of buspirone

This list is not complete. Other drugs may interact with buspirone, including prescription, over-the-counter, vitamin, and herbal products. Not all possible interactions are listed in this medication guide. Dasatinib: Dasatinib inhibits CYP3A4. Therefore, caution is warranted when drugs that are metabolized by this enzyme, such as buspirone, are administered concurrently with dasatinib as increased adverse reactions may occur. Selegiline: Concomitant use of MAOIs and buspirone is contraindicated because several cases of elevated blood pressure have been reported in patients taking MAO inhibitors who were then given buspirone HCL. A 10-day interval after discontinuing isocarboxazid is recommended before initiating buspirone treatment. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Fosphenytoin: Hydantoins are potent inducers of hepatic cytochrome P450 isoenzyme CYP3A4 and may increase the rate of buspirone metabolism. In a study of healthy volunteers, co-administration of buspirone with rifampin decreased the plasma concentrations 83. buy zestril stock



What is buspirone

What other drugs will affect buspirone Buspar? Buspirone is metabolized primarily by oxidation, which in vitro has been shown to be mediated by cytochrome P450 3A4 CYP3A4. Apraclonidine: No specific drug interactions were identified with systemic agents and apraclonidine during clinical trials. Theoretically, apraclonidine might potentiate the effects of CNS depressant drugs such as the anxiolytics, sedatives, and hypnotics, including barbiturates or benzodiazepines. Your doctor may adjust the dose until it is right for you or your child. Activated charcoal is believed to be an effective treatment for overdose, provided the patient is treated promptly. If such symptoms occur, consideration should be given to a possible causal role of the stimulant, and discontinuation of treatment may be appropriate. Respiratory: Infrequent were hyperventilation, shortness of breath, and chest congestion; rare was epistaxis. Store at room temperature away from moisture, heat, and light. David J. Nutt; James C. Ballenger 15 April 2008. Loxapine: The combination of buspirone and CNS depressants like the antipsychotics can increase the risk for sedation. Division of Teva Pharmaceuticals USA, Inc. Hydrocodone: Concomitant use of hydrocodone with other central nervous system depressants, such as buspirone, can potentiate the effects of hydrocodone and may lead to additive CNS or respiratory depression. If hydrocodone is used with buspirone, the dose of one or both drugs should be reduced. They are available in bottles of 100 tablets NDC 57844-130-01. Aggressive behavior or hostility is often observed in children and adolescents with ADHD, and has been reported in clinical trials and the postmarketing experience of some medications indicated for the treatment of ADHD. Although there is no systematic evidence that stimulants cause aggressive behavior or hostility, patients beginning treatment for ADHD should be monitored for the appearance of or worsening of aggressive behavior or hostility. acyclovir



Prescribing information for buspirone

After a 3-day oral aprepitant regimen, the AUC of midazolam given on days 1, 4, 8, and 15 increased by 25% on day 4, and then decreased by 19% and 4% on days 8 and 15, respectively. Very important. A change in your diet, medicine, or dosage may be necessary. Promptly consult your doctor or pharmacist. Alprazolam: It is common for patients to overlap anxiety treatment when switching from benzodiazepines to buspirone. Buspirone has a slow onset of action and the drug will not block the withdrawal syndrome often seen with cessation of benzodiazepine therapy in those with benzodiazepine dependence. Therefore, before starting therapy with buspirone, withdraw patients gradually from the benzodiazepine. Alternatively, conversion to buspirone therapy may require treatment overlap to allow for the downward titration of the benzodiazepine while buspirone takes effect. Sontheimer DL, Ables AZ March 2001. "Is imipramine or buspirone treatment effective in patients wishing to discontinue long-term benzodiazepine use? There is some evidence that buspirone on its own may be useful in the treatment of HSDD in women. Orphenadrine: Concomitant use of skeletal muscle relaxants with buspirone can result in additive CNS depression. Dosage adjustments of either or both medications may be necessary. ziprasidone



Take the medicine pack with you

Difficulties with accommodation and blurring of vision have been reported with stimulant treatment. Amphetamines are excreted in human milk. Mothers taking amphetamines should be advised to refrain from nursing. Amphetamines inhibit the hypotensive effect of veratrum alkaloids. The 5 mg and 10 mg tablets are scored so they can be bisected. Buspirone may cause drowsiness and confusion. Tramadol: Tramadol can cause additive CNS depression when used with other agents that are CNS depressants including buspirone. As such, it is likely to play a significant role in the therapeutic effects of buspirone. Amphetamines can cause a significant elevation in plasma corticosteroid levels. This increase is greatest in the evening. Hydrocodone; Phenylephrine: Concomitant use of hydrocodone with other central nervous system depressants, such as buspirone, can potentiate the effects of hydrocodone and may lead to additive CNS or respiratory depression. If hydrocodone is used with buspirone, the dose of one or both drugs should be reduced. In human and animal studies, buspirone has shown no potential for abuse or diversion and there is no evidence that it causes tolerance, or either physical or psychological dependence. Human volunteers with a history of recreational drug or alcohol usage were studied in two double-blind clinical investigations. None of the subjects were able to distinguish between buspirone and placebo. By contrast, subjects showed a statistically significant preference for methaqualone and diazepam. Studies in monkeys, mice, and rats have indicated that buspirone lacks potential for abuse.



Common side effects of buspirone

Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. United States and its territories. Indications, uses and warnings on Drugs. Sexual Function: Infrequent were decreased or increased libido; rare were delayed ejaculation and impotence. Retrieved 14 November 2013. Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets Mixed Salts of a Single Entity Amphetamine Product is indicated as an integral part of a total treatment program for ADHD that may include other measures psychological, educational, social for patients with this syndrome. Drug treatment may not be indicated for all children with this syndrome. The tablet can be divided into equal doses. Remifentanil: Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of remifentnil, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use is imperative, reduce the dose of one or both drugs if clinically indicated. Lilja JJ, Kivistö KT, Backman JT, Lamberg TS, Neuvonen PJ December 1998. "Grapefruit juice substantially increases plasma concentrations of buspirone". Clinical Pharmacology and Therapeutics. Zileuton: CYP3A4 inhibitors, such as zileuton, may decrease systemic clearance of buspirone leading to increased or prolonged effects. cost of selegiline in canada



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Buspirone adult dosage

Hydromorphone: Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of hydromorphone, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use of codeine and buspirone is imperative, reduce the dose of one or both drugs. Serotonin syndrome, in its most severe form, can resemble neuroleptic malignant syndrome. Several cases of elevated blood pressure have been reported in patients in whom buspirone was added to a non-selective traditional MAO-inhibitor regimen. Voriconazole: Voriconazole is an inhibitor of CYP3A4 isoenzyme. Buspirone is a substrate for CYP3A4, and when combined with voriconazole, may theoretically have reduced metabolism, and therefore higher serum concentrations resulting in toxicity.

The American Journal of Psychiatry

Dronabinol, THC: Use caution if coadministration of dronabinol with buspirone is necessary, and monitor for additive dizziness, confusion, somnolence, and other CNS effects. Erythromycin: Concomitant administration of erythromycin with buspirone may result in significant increases in buspirone AUC; the mechanism is probably reduced buspirone metabolism via CYP3A4. If the two drugs are to be used in combination, a low dose of buspirone is recommended. Subsequent dose adjustment of either drug should be based on clinical assessment. Cyproheptadine: The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation.

Journal of Medicinal Chemistry

Imatinib, STI-571: CYP3A4 inhibitors, such as imatinib, may decrease systemic clearance of buspirone leading to increased or prolonged effects. If buspirone is to be administered concurrently with significant CYP3A4 inhibitors, a low dose of buspirone is recommended initially. What is the dosage for buspirone? Selective serotonin reuptake inhibitors: Because of the potential risk and severity of serotonin syndrome or neuroleptic malignant syndrome-like reactions, caution should be observed when administering selective serotonin reuptake inhibitors SSRIs with other drugs that have serotonergic properties such as buspirone.

Before taking buspirone

An earlier study, published in 2011 in the journal Therapeutic Advances in Neurological Disorders, also found that buspirone may reduce the frequency and severity of Tourette syndrome tics. Mephobarbital: Substances that are potent inducers of hepatic cytochrome P450 isoenzyme CYP3A4, such as barbiturates, may increase the rate of buspirone metabolism. If a patient has been titrated to a stable dosage on buspirone, a dose adjustment of buspirone may be necessary to maintain anxiolytic effect. There is also a risk of additive CNS depression when buspirone is given concomitantly with barbiturates.

Have your pressure checked regularly while taking this medication. Learn how to monitor your own pressure at home, and share the results with your doctor. Alan F. Schatzberg; Charles B. Nemeroff 2009. Amphetamines may counteract the sedative effect of antihistamines.

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